Final answer:
The word 'intrude' has the most negative connotation in the given sentence.
Step-by-step explanation:
The synonym that has the most negative connotation in the given sentence is intrude. To intrude means to invade someone's privacy or space without permission. In this context, using 'intrude' emphasizes that the loud interruptions were unwelcome and disruptive to the otherwise productive meeting.
Learn more about synonyms with negative connotations