Final answer:
The most significant obstacle in building the transcontinental railroad was crossing the Sierra Nevada Range.
Step-by-step explanation:
The MOST significant obstacle in building the transcontinental railroad was d) Crossing the Sierra Nevada Range. The Sierra Nevada Range posed immense challenges due to its rugged terrain, high elevation, and harsh weather conditions. Building tunnels and laying tracks through the mountains required extensive engineering and construction efforts, making this obstacle the most difficult one to overcome in completing the transcontinental railroad.
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