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A young man has been diagnosed with Duchenne muscular dystrophy, which is a X-linked recessive disease. Neither of his parents have the disorder.

a. What are the most likely genotypes of the parents? Explain.








b. Did the allele for the disease come through the maternal or paternal side of the family? Explain.





c. What is the probability that the young man’s sister will also have DMD?




d. Why are male children most likely to exhibit sex-linked traits than female children? Why would this be especially true for sex-linked diseases?

User Sjf
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a. The following are the parents' most likely genotypes:

The mother (XNXn): She has one normal X chromosome (XN) and one X chromosome with the Duchenne muscular dystrophy recessive allele (Xn).

The father (XY) has one X chromosome and one Y chromosome. He must have a normal X chromosome (XN) because he does not have the disease.

b. The allele for Duchenne muscular dystrophy (DMD) originated from the mother. Because the mother is a carrier (XNXn), the boy inherited the X chromosome with the DMD allele from her. The father (XY) provided his Y chromosome, which lacks the DMD allele.

c. It is unlikely that the young man's sister will also have DMD. She will receive one X chromosome from her mother (Xn), which may carry the DMD allele, and one from her father (XN). As a result, her genotype will be XNXn, and she will be a carrier like her mother. However, she is unlikely to get the condition unless she inherits the X chromosome containing the DMD variant from both parents.

d. Male children are more likely than female children to exhibit sex-linked features since they only inherit one X chromosome from their mother, whereas females acquire two X chromosomes. Males have no equivalent X chromosome with the normal allele to hide the effects of the recessive allele if the X chromosome carries a recessive gene for a sex-linked trait. Females, on the other hand, have two X chromosomes. Thus, if one bears a recessive allele, the other X chromosome may have the normal allele, offering protection. This is especially true for sex-linked disorders because males have just one X chromosome and are more likely to express the trait if they receive the recessive allele, but females often require the inheritance of two recessive alleles to express the phenotype.

User Plastikfan
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