Final answer:
The major disagreement between large and small states during the Constitutional Convention of 1787 was related to the calculation of representation in the legislature.
Step-by-step explanation:
The major disagreement between the large and small states during the Constitutional Convention of 1787 occurred over the issue of how to calculate the amount of representation each state would receive in the legislature. This dispute is commonly referred to as the Great Compromise or Connecticut Compromise. The large states, such as Virginia, advocated for representation based on population (known as the Virginia Plan), while the small states, like New Jersey, argued for equal representation for all states (known as the New Jersey Plan).
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