Final answer:
Yellow fever was one of the biggest challenges faced during the construction of the Panama Canal.
Step-by-step explanation:
The disease that was one of the Panama Canal's biggest challenges was yellow fever. Yellow fever is a viral disease transmitted by mosquitoes and causes symptoms such as fever, headache, and jaundice. It was a significant challenge during the construction of the Panama Canal because it affected a large number of workers and caused numerous deaths.
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