Final answer:
Charleston fell to the British in 1780, resulting in the loss of a major port and many colonial leaders.
Step-by-step explanation:
The city that fell to the British in 1780, resulting in the loss of a major port and many colonial leaders, was Charleston. Charleston, located in South Carolina, was a key strategic city during the American Revolutionary War. Its fall to the British was a significant blow to the American colonial cause.
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