Final answer:
The colonists suffered as they tried to adapt to their new environment due to disease outbreaks.
Step-by-step explanation:
One reason the colonists suffered as they tried to adapt to their new environment was due to disease outbreaks. The lack of immunity to new diseases brought by Europeans caused devastating epidemics among Native American populations, leading to high death rates and a decline in labor supply for the colonists.
Learn more about Adaptation challenges faced by colonists