Final answer:
Calico cats are primarily female and the different colored fur is due to X chromosome inactivation.
Step-by-step explanation:
The statement that is false about calico cats is: The variation in coat color is an example of an epistatic interaction.
Calico cats are primarily female due to the genetic mechanism that produces their distinct coat pattern. The different colored fur in calico cats is a result of X chromosome inactivation, where one X chromosome is randomly inactivated in each cell during early development.
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