Final answer:
The Anti-Federalists of the post-war era most condemned the federal response to Shays' Rebellion and the Whiskey Rebellion.
Step-by-step explanation:
The most condemned ''misery'' alluded to by the Anti-Federalists of the post-war era was the federal response to Shays' Rebellion. Shays' Rebellion, which occurred in Massachusetts in 1786-1787, was a protest by farmers against high taxes and debt. The Anti-Federalists saw the federal response to Shays' Rebellion as an example of the central government's power and its potential to suppress individual liberties. This further fueled their concerns about a strong federal government and led to their opposition to the ratification of the U.S. Constitution.
The federal response to the Whiskey Rebellion was also condemned by the Anti-Federalists. The Whiskey Rebellion, which took place in 1794, was a protest in western Pennsylvania against a tax on whiskey imposed by the federal government. The Anti-Federalists viewed the federal government's use of military force to quell the rebellion as an abuse of power and as evidence that the central government could infringe upon the rights of its citizens.
The other options mentioned, organized response to Bacon's Rebellion and federal response to Pontiac's Rebellion, do not pertain to the post-war era or the concerns of the Anti-Federalists.
Learn more about Anti-Federalists' condemnation of federal responses to Shays' Rebellion and the Whiskey Rebellion