Final answer:
The Spanish arrival in America had a profound impact on the native population, resulting in disease outbreaks, loss of life, forced labor, land seizures, and cultural assimilation.
Step-by-step explanation:
The coming of the Spanish to America had a significant impact on the native population. One major effect was the introduction of new diseases, such as smallpox, for which the native population had no immunity. This led to a devastating loss of life among the indigenous people. Additionally, the Spanish colonization resulted in forced labor, land seizures, and cultural assimilation, which further affected the native population.
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