Final answer:
The large vacuole is the structure that differentiates plant cells from animal cells.
Step-by-step explanation:
The structure that best distinguishes plant cells from animal cells is the large vacuole. Plant cells typically have a central large vacuole that occupies most of the cell's volume, while animal cells usually have smaller and multiple vacuoles or none at all. The vacuole in plant cells helps maintain cell turgidity and stores various substances such as water, ions, and pigments.
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