Final answer:
Alexander the Great brought about cultural change through Hellenistic synthesis, spreading Greek culture and ideas throughout the regions he conquered.
Step-by-step explanation:
The sentence that BEST describes how Alexander the Great brought about cultural change is option A: He ushered in a period of Hellenistic synthesis by taking over parts of the Middle East.
Through his conquests, Alexander spread Greek culture and ideas throughout the regions he conquered, resulting in a blending of Greek and local customs known as Hellenistic synthesis. This cultural exchange led to the spread of Greek art, architecture, philosophy, and literature, as well as the adoption of the Greek language and education system in these areas.
For example, cities like Alexandria in Egypt became centers of Hellenistic culture, with libraries and schools attracting scholars from different regions. This cultural influence lasted long after Alexander's death and shaped the future developments in art, science, and philosophy.
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