Final answer:
Members of domain eukarya have cell nucleuses, while members of domain archea do not.
Step-by-step explanation:
One major difference between members of domain eukarya and members of domain archea is that members of domain eukarya have cell nucleuses, while members of archea do not. The presence of a cell nucleus is a defining characteristic of eukaryotes, which include all organisms in domain eukarya. Archaea, on the other hand, are prokaryotes that lack a true nucleus.
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