Final answer:
The plague had a significant impact on the Byzantine Empire, causing death, population decline, economic disruption, and social upheaval.
Step-by-step explanation:
The plague had a devastating impact on the Byzantine Empire, killing a significant number of its residents. The disease, known as the Justinianic Plague or the Plague of Justinian, swept through the empire in the mid-6th century, during the reign of Emperor Justinian I. It caused massive population decline, economic disruption, and social upheaval.
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