149k views
3 votes
Sickle cell hemoglobin AA sequence

1 Answer

6 votes
The amino acid sequence for normal adult hemoglobin (HbA) in individuals with the AA genotype (homozygous for normal hemoglobin) is as follows:

\[ \text{Val}-\text{His}-\text{Leu}-\text{Thr}-\text{Pro}-\text{Glu}-\text{Glu} \]

In this sequence:
- \(\text{Val}\) stands for Valine (Val)
- \(\text{His}\) stands for Histidine (His)
- \(\text{Leu}\) stands for Leucine (Leu)
- \(\text{Thr}\) stands for Threonine (Thr)
- \(\text{Pro}\) stands for Proline (Pro)
- \(\text{Glu}\) stands for Glutamic acid (Glu)

This sequence represents the first six amino acids of the beta-globin chain of hemoglobin, which is the major component of HbA.
User Dejan Skledar
by
7.9k points