There are 11 letters in MATHEMATICS.
These 11 letters can be permuted in 11 positions.
But, some letters are repeating - M (2 times), A (2 times), T (2 times)
So this is how we will do it:

= 39916800 / 8
= 4989600
Answer: 4989600 distinct permutations can be formed using the letters of the word MATHEMATICS.