To calculate the amount of the medication Maria should give, you can use the concentration of the solution, which is 250 mg/mL, and the ordered dose of 500 mg.
The formula to find the volume (in mL) of the solution to give is:
Volume (mL) = Dose (mg) / Concentration (mg/mL)
In this case:
Volume (mL) = 500 mg / 250 mg/mL = 2 mL
Maria should give 2 mL of the solution to administer the ordered dose of 500 mg.