Question

What type of molecules have difficulty diffusing across the cell membrane?

Answer 1

Molecules that have difficulty diffusing across the cell membrane include those that are large, highly charged, and/or hydrophilic.

Step-by-step explanation:

Molecules that have difficulty diffusing across the cell membrane include those that are large, highly charged, and/or hydrophilic.

For example, proteins are large molecules that cannot easily pass through the cell membrane without the help of specific transport mechanisms such as protein channels or pumps.

Similarly, ions with a high charge, such as sodium (Na+) and chloride (Cl-), face difficulty in diffusing across the cell membrane.

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