Final answer:
The novel that depicts the struggles of an Oklahoma family during the Great Depression is The Grapes of Wrath.
Step-by-step explanation:
The Depression-era novel that chronicled the misery of a family of Oklahoma tenant farmers who migrated to California in search of work is The Grapes of Wrath. Written by John Steinbeck, the novel portrays the hardships faced by the Joad family as they experience poverty, unemployment, and exploitation during the Great Depression. It highlights the social and economic inequality prevalent during that era.
Learn more about Depression-era novel and the Great Depression