False. In 1506, Christopher Columbus died in Valladolid, Spain, not in his native Italy. Columbus was born in the Republic of Genoa (now part of Italy) in 1451, but he spent most of his life exploring and making voyages on behalf of Spain.
After his historic voyage in 1492, Columbus made three more voyages across the Atlantic, exploring various Caribbean islands, Central and South America. He never returned to Italy during his expeditions. Columbus passed away on May 20, 1506, in Valladolid, Spain, at the age of 54.
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Christopher Columbus, Italian Cristoforo Colombo, Spanish Cristóbal Colón, (born between August 26 and October 31?, 1451, Genoa [Italy]—died May 20, 1506, Valladolid, Spain), master navigator and admiral whose four transatlantic voyages (1492–93, 1493–96, 1498–1500, and 1502–04) opened the way for European exploration