Question

In disorders with autosomal recessive inheritance, the affected children have received a disease-causing mutation from both parents. In the family shown in the pedigree, we can conclude that the parents are both healthy, heterozygous carriers of the mutation. What is the risk that their second child will develop the disease just as their first daughter? a) 0% risk b) 25% risk c) 50% risk d) 100% risk

Answer 1

In autosomal recessive disorders, the risk of a second child developing the disease is 25% when both parents are heterozygous carriers of the mutation.

Step-by-step explanation:

In disorders with autosomal recessive inheritance, the affected children have received a disease-causing mutation from both parents. In the family shown in the pedigree, where both parents are healthy heterozygous carriers of the mutation, their second child has a 25% risk of developing the disease just like their first daughter.

This is because both parents are carriers of the mutation, and for each child they have, there is a 25% chance of inheriting two copies of the disease-causing mutation, resulting in the development of the disease.

Learn more about Autosomal recessive inheritance