We want to know the probability of choosing two letters at random, and the first letter is a consonant and the second one is a vowel. The word we are given is
MATHEMATICS
We see that it has 7 consonants and 4 vowels. We will denote by E to the event:
As the events: "Obtaining a consonant" and "Obtaining a vowel" are independent, we get:
This means that the probability that the first letter is a consonant and the second letter is a vowel is (approximately) 25.45%.