Final answer:
The inhibition of cholesterol absorption occurs in the small intestine during lipid metabolism. Large hydrophobic fatty acids, monoacylglycerides, and cholesterol are enclosed in a micelle facilitated by bile salts and lecithin. These micelles reach the luminal cell surface where their contents are absorbed, however, certain mechanisms can inhibit cholesterol absorption.
Step-by-step explanation:
The inhibition of cholesterol absorption occurs primarily in the small intestine during the process of lipid metabolism. Ingested triglycerides are broken down into smaller chain fatty acids and subsequently into monoglyceride molecules by pancreatic lipases after they are emulsified by bile salts. About 95 percent of lipids are absorbed in the small intestine. Large and hydrophobic long-chain fatty acids and monoacylglycerides, along with cholesterol, are enclosed in a micelle which creates a receptive environment for the cholesterol. These micelles can squeeze through microvilli, reaching the luminal cell surface where they release their contents, including cholesterol, for absorption. However, certain mechanisms can inhibit the absorption of cholesterol, preventing it from entering the bloodstream.
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