Final answer:
Shigatoxin, mainly produced by some strains of E.coli and S. dysenteriae, is primarily associated with hemolytic uremic syndrome (HUS). It enters endothelial cells of small blood vessels within the intestines and kidneys, altering their protein synthesis and potentially leading to kidney failure.
Step-by-step explanation:
Content loaded Shigatoxin is associated with primarily the hemolytic uremic syndrome (HUS). Produced by certain bacteria such as E.coli and S. dysenteriae, Shiga toxin targets the endothelial cells of small blood vessels in the intestines and kidneys. It binds to a glycosphingolipid, enters the endothelial cells, and affects their protein synthesis by targeting their large ribosomal subunit. This can result in hemorrhagic colitis, characterized by lesions and hemorrhaging in the colon. The worst outcome can be HUS, a severe condition where damage to red blood cells leads to potential kidney failure.
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