Final answer:
The most supported reaction from 'The Birthmark' is that Georgiana regrets marrying Aylmer, as supported by the detailed descriptions of Aylmer's views on her birthmark as a flaw and her own resulting self-rejection.
Step-by-step explanation:
The reaction that is most supported by the ideas and details in Nathaniel Hawthorne's text 'The Birthmark' is option C: Georgiana must regret marrying Aylmer because he believes she is flawed. The text provides several insights into Aylmer's obsessive quest to remove Georgiana's birthmark, which he views as an imperfection. Georgiana, influenced by Aylmer's perspective, begins to detest her own birthmark to the point where it affects her feelings of self-worth, as depicted in the passage where she is deeply affected by the presence of the birthmark on her cheek. There are no specific references supporting options A, B, or D as the most significant reaction derived from the text.