Final answer:
Beta amyloid 42, associated with Alzheimer's, increases with the activation of the nervous system. Notably, the limbic system within the brain plays a significant role in this process. Stress responses particularly exacerbate the abnormal protein production.
Step-by-step explanation:
Beta amyloid 42 increases when the nervous system is activated. Often associated with neurodegenerative diseases like Alzheimer's, the beta-amyloid plaques are a result of proteins behaving anomalously. These proteins form dense conglomerations, which fail to function as intended.
The activation of the nervous system has a significant roleplay in instigating the accumulation of these plaques. This happens particularly within the brain's emotional circuit, otherwise known as the limbic system. The limbic system, which includes both the amygdala and the hippocampus, experiences increased activity during emotional processes and especially during states of fear or anxiety.
Stressful stimuli provoke amygdala signals to the hypothalamus which in turn stimulates the release of stress hormones via the endocrine system. Continued instances of such stress responses can exacerbate the abnormal beta amyloid 42 production.
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