Question

As a member of bcl-2 family of BH3 only containing proteins,

this protein is liberated from its association with bcl-2 and then
acts to promote autophagy.
a.BRCA
b.BCRA
c.BARC
d.Beclin

Answer 1

Beclin-1 is a protein that belongs to the BH3-only subfamily of the Bcl-2 family of proteins. It plays an important role in the regulation of autophagy, a process by which cells break down and recycle their own components. Beclin-1 promotes autophagy by interacting with other proteins to form a complex that initiates the process of autophagosome formation.

Under normal conditions, Beclin-1 is sequestered in complexes with anti-apoptotic proteins of the Bcl-2 family, such as Bcl-2 itself. However, under conditions of cellular stress, Beclin-1 is released from these complexes, allowing it to participate in autophagy induction.

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