Answer:
The quote reflects the pervasive sense of hopelessness and despair that exists on the reservation, which is a major theme of the novel.
Junior makes this statement after the death of his friend Oscar, who was killed by another member of their community. Junior is reflecting on the fact that life on the reservation is so difficult and oppressive that some people are willing to resort to violence to escape it. He is also acknowledging the fact that, in this context, death is a cheap and easy way out.
The quote speaks to the larger issues that Junior faces as an Indian living on the reservation, including poverty, alcoholism, and a lack of opportunity. It highlights the fact that life on the reservation can be so difficult that people may feel that there is no other way out.