Step-by-step explanation:
When a weak base drug is administered orally and enters the stomach, which has a pH of 2, the drug will tend to be in its un-ionized form due to the low pH. This is because weak bases tend to exist in an un-ionized (non-charged) form in acidic environments. The un-ionized form of the drug is typically more lipophilic (fat-soluble) and can more easily cross membranes and be absorbed into the bloodstream.
As a result, the weak base drug is likely to be well absorbed in the stomach due to its un-ionized form. However, once it enters the small intestine, which has a higher pH, the drug may become ionized and less lipophilic, making it more difficult to cross membranes and be absorbed. This is why some weak base drugs are formulated with enteric coatings or other methods to delay their release until they reach the small intestine, where they can be more effectively absorbed.