Answer:
False.
Step-by-step explanation:
Crossing-over, also known as recombination, occurs during the meiotic division of cells, and it involves the exchange of genetic material between homologous chromosomes.
Non-homologous chromosomes are not similar in their genetic content and do not pair up during meiosis, so they cannot participate in a crossing-over event.
In summary, crossing-over is a process that can only occur between homologous chromosomes.