The metaphorical use of "artery" in the sentence most likely suggests that Route 66 is a vital method for transporting goods and services. An artery is a blood vessel that carries oxygen-rich blood from the heart to the rest of the body, and is thus a crucial part of the circulatory system that sustains life. In the context of the sentence, the word "artery" is used to emphasize the importance of Route 66 as a transportation route that connects different parts of the country and facilitates the flow of people and goods. Therefore, the most appropriate response is: "a vital method for transporting goods and services".