Final answer:
Patrick Henry was an Anti-Federalist who believed a strong central government could threaten individual rights and states' powers, distinct from Federalists like Madison, Jay, and Hamilton.
Step-by-step explanation:
The Anti-Federalist among the options provided is Patrick Henry. As an opponent of the ratification of the Constitution, Patrick Henry represented the Anti-Federalist view that a strong central government could endanger the rights of individuals and the prerogatives of the states. In contrast, James Madison, John Jay, and Alexander Hamilton were all Federalists and among the authors of the The Federalist Papers, advocating for a stronger national government as outlined in the Constitution.