In genetics, a mutation is a change that occurs in the DNA sequence of an individual. This change can affect the genetic information passed from one generation to another. Mutations can occur spontaneously, or they can be caused by environmental factors such as radiation or exposure to chemicals. In human genetics, mutations can lead to genetic disorders or predisposition to certain diseases. Some mutations may have no effect at all, while others may have a significant impact on an individual's health and well-being.