Answer:
What role does actual ATP hydrolysis play in the function of the proteasome? ATP hydrolysis is required for the substrate to unfold. What is ubiquitin ligase? Ubiquitin ligase is an enzyme that is responsible for targeting specific protein substrates for degradation by the proteasome.
Step-by-step explanation:
ATP Binding Is Necessary and Sufficient for Assembly, Activation, and Stability of the 26S Proteasome. We and others previously demonstrated ATP-dependent in vitro assembly of 26S proteasome from purified 20S proteasome and PA700 (DeMartino et al., 1994; Ma et al., 1994; Hoffman et al., 1992).