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In the innate immune system are dendritic cells found in tissue mature before they encounter any antigen or microbe?

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no

The function of dendritic cells is not primarily to destroy pathogens but to carry pathogen antigens to peripheral lymphoid organs and there present them to T lymphocytes. When a dendritic cell takes up a pathogen in infected tissue, it becomes activated, and travels to a nearby lymph node. On activation, the dendritic cell matures into a highly effective antigen-presenting cell (APC) and undergoes changes that enable it to activate pathogen-specific lymphocytes that it encounters in the lymph nodes. Activated dendritic cells secrete cytokines that influence both innate and adaptive immune responses, making these cells essentia

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