Answer:
Step-by-step explanation:
-If this drug is used during pregnancy, it should be discontinued at least 2 weeks before the expected delivery date.
.Renal Dose Adjustments
Use with caution; initial and maintenance doses should be conservative to avoid hypoglycemic reactions
Initial dose: 1.25 mg (standard) or 0.75 mg (micronized) orally once a day
Liver Dose Adjustments
Use with caution; initial and maintenance doses should be conservative to avoid hypoglycemic reactions
Initial dose: 1.25 mg (standard) or 0.75 mg (micronized) orally once a day
Dose Adjustments
Initial and maintenance doses should be conservative in patients at risk for serious hypoglycemic reactions
Initial dose: 1.25 mg (standard) or 0.75 mg (micronized) orally once a day
Micronized glyburide tablets (Glynase Prestab) are not bioequivalent to standard glyburide formulations (DiaBeta, Micronase); patients should retitrate dose when transferring from one formulation to the other
No exact dosage relationship exists between glyburide and other oral hypoglycemic agents; however, a maintenance dose of glyburide 5 mg/day provides approximately the same degree of blood glucose control as chlorpropamide 250 to 375 mg/day, tolazamide 250 to 375 mg/day, acetohexamide 500 to 750 mg/day, or tolbutamide 1000 to 1500 mg/day.
Patients should not exceed maximum starting doses when switching agents
Precautions
CONTRAINDICATIONS:
Hypersensitivity to the active substance or any product excipients
Type 1 diabetes mellitus
Diabetic ketoacidosis, with or without coma
Concomitant administration of bosentan
Hypoglycemia may occur, especially in the elderly, debilitated, or malnourished patient, in patients receiving combination therapy, and/or those with renal, hepatic or adrenal insufficiency; dose reduction of this drug may be necessary.
This drug should not be used in patients with type 1 diabetes or diabetic ketoacidosis.
Hemolytic anemia may occur in glucose 6-phosphate dehydrogenase (G6PD) deficient patients; consider a non-sulfonylurea alternative.
When a patient stabilized on any diabetic regimen is exposed to stress such as fever, trauma infection, or surgery, it may be necessary to stop this drug and administer insulin.