Answer: Several North Carolina rivers flow into the Mississippi River basin. These include:
The French Broad River
The Nolichucky River
The Pigeon River
The Little Tennessee River
The Hiwassee River
The Ocoee River
The Conasauga River
The Coosawattee River
The Cartoogechaye River
The Nottely River
This list is not exhaustive and there may be other rivers that also flow into the Mississippi River basin in North Carolina.