All cytoskeletal elements have specific functions and structural characteristics that make them susceptible to different types of damage or disruption. However, the microtubules are considered the most susceptible cytoskeletal element. Microtubules are flexible, hollow tubes made up of a protein called tubulin. They are responsible for maintaining cell shape, cell division, and organelle movement. Because of their dynamic nature, microtubules are more susceptible to damage caused by environmental factors such as temperature changes, pH changes, and exposure to chemicals. Additionally, microtubules are also more susceptible to disruption caused by certain drugs and toxins that target tubulin, such as the chemotherapy drug taxol.