Answer:
1. The arrival of Christopher Columbus and his crew in the Americas brought new diseases to the indigenous populations, which decimated their numbers.
2. Columbus and his men enslaved many indigenous people and forced them to work in gold mines and on plantations.
3. The arrival of Europeans also brought about significant changes to the indigenous way of life, including the loss of land and resources as well as the forced adoption of Christianity.
These are just a few of the major things.