In taking simvastatin, it should be taken at bed time or during supper. If you are prescribed to take this drug more than once a day, it should after a meal. It is taken for long-terms for periods for treating high cholesterol but should stopped in case of surgery or medical emergency. If you miss a dose, take the dose you miss as soon as possible and if it was too long, take it on the next schedule. If a patient overdoses on the drug call for emergency medical assistance.