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From the 1830s on, people hoping to settle in the Northwest A-were stopped by the Cumberland Gap. B-traveled along the Oregon Trail. C-followed a trail blazed by Zebulon Pike. D-were stopped by the Great Plains.

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Generally speaking, from the 1830s on, people hoping to settle in the Northwest "B-traveled along the Oregon Trail," since this had become a well-established route. 
User Andre Schweighofer
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