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What were two main causes of the bitter rivalry between the Ottoman and Safavid empires?

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One of the main causes is that Safavid attached the capital of the Ottoman and they thought they were like the real Muslims.

User Irgend Son Hansel
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1) ottomans were sunni muslims while safavids were shia 2) they rivaled over the domination of iraq and the caucasus (georgia, armenia, azerbaijan present day)
User Iurii Dziuban
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