Question

The recombination frequency between three genes A, B, and C located on the same chromosome is obtained as follows:

A and C – 28%
A and B – 18%
B and C – 10%
Based on the result, which two genes are closest to each other?

Answer 1

Genes B and C with 10% recombination frequency are closest to each other. Because recombination happens at random, the distance between genes that are farther from each other creates higher recombination frequency. A low recombination frequency of 10% means the genes are closest to each other. The short distance between the two genes allow fewer recombination to happen, thus the frequency is low.