Question

How did the use of Spanish missions affect the spread of disease in the Americas?

Answer 1

Thousands of American Indians were exposed to diseases at Spanish missions.

Explanation:thats the answer

Answer 2

Because the spanish brought new diseases that the americans have never had before, the americans didnt have anything to fight against the disease with so they had to find new ways to fight against new sickness to defend againt any further new disease/ death.