Final answer:
It is true that after the Treaty of Paris, England was not friendly with the United States, as the treaty failed to fully mend the strained relations and led to the War of 1812. The Treaty of Paris also largely ignored the American Indians, and the protection of Loyalists after the treaty was ineffective.
Step-by-step explanation:
The statement 'After the Treaty of Paris, England was not friendly with the United States' is True. While the Treaty of Paris marked the end of the American Revolutionary War and started a new era of peace, relations between England and the United States were strained. The treaty's articles were not completely adhered to, and Britain was reluctant to evacuate certain areas. Additionally, the persecution of Loyalists persisted, and issues concerning American sovereignty and shipping rights led to tensions that eventually culminated in the War of 1812.
Regarding the other statements: For all practical purposes, the Treaty of Paris ignored the American Indians is True. The document failed to address the interests of the Indian tribes that participated in the war. Also, it is False that 'Both the Americans and the British gave up claims to the Mississippi for the sake of peace' as the treaty actually recognized American rights to the territory east of the Mississippi River, excluding Florida. Lastly, the claim that 'Loyalists were protected by the treaty and well treated after it was signed' is False. The Loyalists often faced persecution and their protection under the treaty was not effectively guaranteed.