Final answer:
The United States' isolationist stance shifted to intervention after the attack on Pearl Harbor on December 7, 1941, which led to its entry into World War II and indicated a new era of active global engagement.
Step-by-step explanation:
The tipping point at which the United States could no longer be considered an isolated nation occurred with its entry into World War I. However, it was after Japan's attack on Pearl Harbor on December 7, 1941, that the United States could no longer avoid involvement in World War II. This attack was a direct catalyst that thrust the U.S. into global conflict and marked the end of its isolationist policies. Between the World Wars, America adopted a stance of isolation, focusing inwardly on growth through immigration, industrialization, and technological advancements. Despite these isolationist tendencies, the outbreak of World War II and the direct attack on American soil made it clear that involvement was necessary for national and international security.
The creation of the United Nations post World War II signified America's new role as a global leader and marked a permanent shift from an isolationist policy to one of active engagement. America's response during this era shapes much of its current foreign policies, indicating a fundamental change in how the nation views its place in world affairs. The era between the First and Second World Wars was a turning point for American isolationism, as the nation moved towards intervention in the interest of its security and global stability.