Final answer:
The bubonic plague followed established trade routes, notably the Silk Road, and had a widespread impact beyond Europe, affecting Asia, the Middle East, and North Africa during the fourteenth century.
Step-by-step explanation:
Among the presented options about the bubonic plague, the correct statement is that (A) It followed established trade routes. The bubonic plague, also known as the Black Death, significantly impacted the world in the fourteenth century by spreading along trade routes, including the Silk Road. Initially striking China, it moved through the Mongol Empire, the Arabic world, and subsequently Europe, causing devastating demographic and socioeconomic effects. It was not solely a European phenomenon, as it affected vast regions of Asia, the Middle East, North Africa, and has been suggested, parts of sub-Saharan Africa. Furthermore, the plague did not originate in Europe nor did it cease to exist after the fourteenth century, with waves continuing into later centuries and occasional outbreaks occurring in the modern era.