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In an experiment to test a new drug’s effectiveness, one group is given a larger dosage than is typically prescribed, and a second group is given a smaller dosage than is typically prescribed. Then, the results of the groups are compared to each other. What is missing that would improve this scientific design?

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One group is given a larger dosage than is typically prescribed.
A second group is given a smaller dosage than is typically prescribed
Then results of the groups are compared to each other.

The thing that is missing in this experimental design is a third group who are tested with the typical dosage.
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