Final answer:
Mehmet II overcame the strategic blocking of the Golden Horn by the Byzantines through a combination of military tactics and advanced weaponry. He assembled a fleet of ships to block sea reinforcements, used bombards to breach city walls, and received support from his vassals and elite soldiers.
Step-by-step explanation:
Mehmet II, also known as Mehmed the Conqueror, overcame the strategic blocking of the Golden Horn by the Byzantines by using a combination of military tactics and advanced weaponry. Firstly, he assembled a large fleet of newly constructed ships to prevent Constantinople from receiving reinforcements and supplies via the sea.
Additionally, Mehmet brought in European gunsmiths to craft powerful bombards, which were early forms of cannon, to bombard and breach the city walls. These tactics, along with the help of his Muslim and Christian vassals and a core of elite professional soldiers, enabled Mehmet to successfully conquer Constantinople in the year 1453.