Alexander the Great led several conquering campaigns from Macedon, Greece, Egypt, Persia, to India. He spread Greek thought and culture in his wake, After his death this huge Empire was divided among his four generals:
Lysimachus - A large portion of Asia Minor and Thrace.
Seleucos I- The other portion of Asia. Besides, founded Mesopotamia, Levant, Persia, and part of India.
Ptolemy I - Palestine, Egypt, Cyprus, Petra, Cilicia.
Cassander - Greece, Macedonia.